Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Solensia for Cats
Solensia is a monthly injection that controls osteoarthritis pain in cats. It's the first FDA-approved monoclonal antibody therapy for feline OA — a major advance for cats since most NSAIDs aren't safe long-term in cats.
What Solensia is used for in cats
- Osteoarthritis pain in cats
How it works
Frunevetmab neutralizes nerve growth factor (NGF), the protein that amplifies arthritis pain signals. Targeted at cat NGF specifically.
Available formulations
Injectable solution (vet-administered)
Side effects to know
Common side effects
- • Mild lethargy after injection
- • Decreased appetite
- • Vomiting (rare)
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Injection site reaction
- ⚠ Allergic reaction (uncommon)
Drug interactions
- • Concurrent NSAID use generally avoided
When not to use
- • Cats under 1 year of age
- • Pregnant or nursing cats
- • Cats with documented hypersensitivity
Monitoring during treatment
Recheck at 3 months to assess response. Most cats show improvement after 1-2 doses.
Talk to a vet about Solensia
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video for $64.99 per visit.
Book a vet visit — $64.99Solensia for Cats
Frequently asked questions
How quickly does Solensia work?
Most cats show pain improvement within 7 days, with full effect by the second monthly dose.
Is Solensia safer than NSAIDs for cats?
Yes — cats don't tolerate long-term NSAIDs well (kidney risk). Solensia targets pain at the source without the kidney concerns. It's a major step forward for chronic feline arthritis pain.
How often does Solensia need to be given?
Monthly injection at your vet. Some cats respond to a slightly extended interval after the initial doses.
Can RexVet prescribe Solensia?
Solensia must be administered by a vet (it's an injection). RexVet can review whether Solensia is appropriate and refer to an in-person clinic for the injection.
How do I know if my cat has arthritis?
Signs include: reluctance to jump up or down, stiffness after rest, hiding more, less grooming, less litter box use (if box is high), aggression when touched. A vet exam confirms.
How much does Solensia for cats cost?
Solensia is a monthly injection given at a veterinary clinic, so there is no single price: each clinic sets its own fee, usually as part of the visit, and it varies by region, by clinic and by the cat, because the dose is based on the cat's weight. Ask the clinic that will give the injection for a quote that includes the exam and any recheck, and expect it to be an ongoing monthly expense for as long as your cat stays on it.
Can I buy Solensia online?
No. Solensia is a prescription injection that federal law restricts to use by or on the order of a licensed veterinarian, and it is not sold for owners to give at home. The label calls for the contents of a single-use, refrigerated, preservative-free vial to be drawn into a syringe and injected immediately, with a specific warning about accidental self-injection. Vets administer it in the clinic. RexVet can discuss whether Solensia suits your cat and refer you to a local clinic for the injections.
How is the Solensia injection given?
Per the FDA label, Solensia (frunevetmab) is given by subcutaneous injection, under the skin, once a month by a veterinarian. The amount is chosen from a weight-range chart, drawn from one or more single-use vials into a syringe and given right away. Most cats show improvement within days of the first dose, and it can take more than one monthly injection to reach the full effect, so your vet will typically recheck after the first few doses.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.