Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Solensia for Cats
Solensia is a monthly injection that controls osteoarthritis pain in cats. It's the first FDA-approved monoclonal antibody therapy for feline OA — a major advance for cats since most NSAIDs aren't safe long-term in cats.
What Solensia is used for in cats
- Osteoarthritis pain in cats
How it works
Frunevetmab neutralizes nerve growth factor (NGF), the protein that amplifies arthritis pain signals. Targeted at cat NGF specifically.
Available formulations
Injectable solution (vet-administered)
Side effects to know
Common side effects
- • Mild lethargy after injection
- • Decreased appetite
- • Vomiting (rare)
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Injection site reaction
- ⚠ Allergic reaction (uncommon)
Drug interactions
- • Concurrent NSAID use generally avoided
When not to use
- • Cats under 1 year of age
- • Pregnant or nursing cats
- • Cats with documented hypersensitivity
Monitoring during treatment
Recheck at 3 months to assess response. Most cats show improvement after 1-2 doses.
Need a Solensia refill?
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video, get your cats's Solensia prescription, and have it shipped through RexVetRx — all for $64.99 per visit.
Book a vet visit — $64.99Solensia for Cats
Frequently asked questions
How quickly does Solensia work?
Most cats show pain improvement within 7 days, with full effect by the second monthly dose.
Is Solensia safer than NSAIDs for cats?
Yes — cats don't tolerate long-term NSAIDs well (kidney risk). Solensia targets pain at the source without the kidney concerns. It's a major step forward for chronic feline arthritis pain.
How often does Solensia need to be given?
Monthly injection at your vet. Some cats respond to a slightly extended interval after the initial doses.
Can RexVet prescribe Solensia?
Solensia must be administered by a vet (it's an injection). RexVet can review whether Solensia is appropriate and refer to an in-person clinic for the injection.
How do I know if my cat has arthritis?
Signs include: reluctance to jump up or down, stiffness after rest, hiding more, less grooming, less litter box use (if box is high), aggression when touched. A vet exam confirms.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.