Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Mirataz for Cats
Mirataz is a transdermal (skin-applied) appetite stimulant for cats with weight loss or decreased appetite. It's FDA-approved specifically for cats.
What Mirataz is used for in cats
- Weight loss in cats
- Decreased appetite
- Chronic kidney disease support
How it works
Mirtazapine stimulates appetite by acting on serotonin and histamine receptors. The transdermal formulation is applied to the inner ear, where it absorbs through the skin — no pilling needed.
Available formulations
Transdermal ointment (Mirataz brand, FDA-approved)
Oral tablet (off-label compounded)
Side effects to know
Common side effects
- • Mild sedation
- • Vocalization
- • Redness at application site
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Serotonin syndrome (with other serotonergic drugs)
- ⚠ Severe sedation
Drug interactions
- • SSRIs
- • MAOIs
- • Tramadol
- • Trazodone
When not to use
- • Cats with documented mirtazapine sensitivity
- • Concurrent MAOI use
Monitoring during treatment
Wear gloves when applying. Apply to fur-free inner ear, alternating ears each day. Wipe excess off with a damp cloth if needed.
Need a Mirataz refill?
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video, get your cats's Mirataz prescription, and have it shipped through RexVetRx — all for $64.99 per visit.
Book a vet visit — $64.99Mirataz for Cats
Frequently asked questions
How fast does Mirataz work?
Most cats show interest in food within 1-2 hours of the first dose. Effect lasts 24 hours.
Why is Mirataz transdermal instead of oral?
Cats hate pills. The transdermal formulation absorbs through the inner ear skin — no pilling required, easier for owners, less stressful for cats.
Can RexVet prescribe Mirataz?
Yes — for cats with documented weight loss or appetite issues, a RexVet video visit can result in Mirataz through RexVetRx.
Is Mirataz safe long-term?
Yes, when used as directed. Many CKD cats stay on Mirataz long-term to maintain appetite.
Do I need to wear gloves applying Mirataz?
Yes — mirtazapine can absorb through human skin too. Always wear gloves and wash hands.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.