Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Prednisolone for Cats
Prednisolone is a corticosteroid prescribed in cats for inflammatory and immune-mediated diseases. Cats metabolize prednisolone better than prednisone, so vets typically prescribe prednisolone for feline patients.
What Prednisolone is used for in cats
- Inflammatory bowel disease
- Asthma
- Some autoimmune diseases
- Some cancers (e.g. lymphoma)
- Severe allergic reactions
How it works
Prednisolone suppresses inflammation and immune activity broadly. It's powerful but non-specific — short courses are safer than long-term use.
Available formulations
1 mg tablet
5 mg tablet
Oral suspension
Side effects to know
Common side effects
- • Increased thirst and urination
- • Increased appetite
- • Mild lethargy
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Diabetes mellitus
- ⚠ Severe immunosuppression
- ⚠ Behavior changes
Drug interactions
- • NSAIDs (do not combine)
- • Insulin
- • Live vaccines
When not to use
- • Active untreated infection
- • Diabetes (use carefully)
- • Concurrent NSAID therapy
Monitoring during treatment
Long-term use needs periodic bloodwork and urinalysis. Never stop suddenly — always taper.
Need a Prednisolone refill?
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video, get your cats's Prednisolone prescription, and have it shipped through RexVetRx — all for $64.99 per visit.
Book a vet visit — $64.99Prednisolone for Cats
Frequently asked questions
Prednisolone vs prednisone for cats?
Cats convert prednisone to prednisolone less efficiently than dogs. Vets typically prescribe prednisolone directly for cats to ensure consistent levels.
How long can my cat take prednisolone?
Short courses (1-3 weeks) are very common. Some conditions (IBD, asthma) require long-term low-dose treatment. Periodic bloodwork monitors for side effects.
Can RexVet refill prednisolone?
Yes — for established conditions with current bloodwork. RexVet manages chronic IBD and asthma cases via video visit.
Why is my cat so thirsty on prednisolone?
Increased thirst and urination are the most common side effects. They usually fade as the dose tapers. Provide plenty of water and accept more litter box use.
Can I stop prednisolone suddenly?
No — after more than 2 weeks of use, always taper. Sudden stopping can cause an Addisonian crisis.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.