Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Rimadyl for Dogs
Rimadyl is one of the most-prescribed dog NSAIDs. It relieves pain and inflammation from arthritis, joint disease, and post-surgical recovery.
What Rimadyl is used for in dogs
- Osteoarthritis pain in dogs
- Post-surgical pain control
- Soft tissue injury inflammation
- Some inflammatory conditions
How it works
Rimadyl selectively inhibits the COX-2 enzyme involved in inflammation while preserving more of the COX-1 enzyme that protects the stomach lining. This makes it gentler on the GI tract than older NSAIDs.
Available formulations
25 mg chewable
75 mg chewable
100 mg chewable
Caplet
Side effects to know
Common side effects
- • Mild GI upset
- • Decreased appetite
- • Diarrhea
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Black/tarry stools (GI bleeding)
- ⚠ Vomiting blood
- ⚠ Yellowing of eyes or gums (liver issues)
- ⚠ Sudden behavior change
- ⚠ Decreased urination (kidney issues)
Drug interactions
- • Corticosteroids (e.g. prednisone) — do not combine
- • Other NSAIDs
- • Some diuretics
- • ACE inhibitors (with kidney monitoring)
When not to use
- • Concurrent steroid use
- • Pre-existing kidney or liver disease
- • Bleeding disorders
- • Dogs with active gastrointestinal ulcers
- • Dehydrated dogs
Monitoring during treatment
Baseline and periodic bloodwork (every 6-12 months for long-term use) checking kidney and liver function. Stop immediately and call your vet if any serious side effect appears.
Need a Rimadyl refill?
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video, get your dogs's Rimadyl prescription, and have it shipped through RexVetRx — all for $64.99 per visit.
Book a vet visit — $64.99Rimadyl for Dogs
Frequently asked questions
How long does it take Rimadyl to work?
Most dogs show pain relief within 1-2 hours of the first dose, with full effect within 24-48 hours. For arthritis, the cumulative benefit may continue improving over the first week.
Can I give Rimadyl with food?
Yes — giving with food helps reduce stomach upset and is generally recommended.
Is Rimadyl safe long-term?
Yes when monitored properly. Many arthritic dogs take Rimadyl for years. Periodic bloodwork is the key to catching kidney or liver issues early.
Can RexVet refill my dog's Rimadyl?
Yes, for dogs with an established diagnosis and recent bloodwork. RexVet can schedule a video check-in and send the refill through RexVetRx.
What if I miss a Rimadyl dose?
Give it when you remember unless it's close to the next scheduled dose — then skip and continue normally. Never give two doses at once.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.