Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Trazodone for Dogs
Trazodone is a prescription medication used in dogs for short-term anxiety and behavior calming — typically before vet visits, fireworks, thunderstorms, or to support post-surgical rest.
What Trazodone is used for in dogs
- Pre-visit anxiety
- Storm and noise phobia
- Post-surgical rest/restriction periods
- Travel-related stress
How it works
Trazodone modulates serotonin receptors in the brain, producing a calming effect without heavy sedation in most dogs. It typically takes effect within 1-2 hours.
Available formulations
50 mg tablet
100 mg tablet
150 mg tablet
300 mg tablet
Side effects to know
Common side effects
- • Sedation
- • Lethargy
- • Mild gastrointestinal upset
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Serotonin syndrome (rapid heart rate, tremors, hyperthermia)
- ⚠ Extreme sedation
- ⚠ Aggression in rare cases
Drug interactions
- • Other serotonergic drugs (SSRIs, MAOIs, tramadol)
- • Sedatives and tranquilizers (additive effect)
- • Some antifungals (azoles) may increase trazodone levels
When not to use
- • Dogs with known serotonin syndrome risk
- • Concurrent MAOI therapy
- • Severe liver disease
Monitoring during treatment
First doses should be given when you can observe your dog for 2-3 hours. Note sedation level so future doses can be adjusted.
Need a Trazodone refill?
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video, get your dogs's Trazodone prescription, and have it shipped through RexVetRx — all for $64.99 per visit.
Book a vet visit — $64.99Trazodone for Dogs
Frequently asked questions
How fast does trazodone work in dogs?
Trazodone typically takes effect within 1-2 hours. For a vet visit or storm, give it about 90 minutes before the trigger.
Will my dog be groggy on trazodone?
Most dogs experience mild sedation that lets them rest without being fully knocked out. If your dog seems too groggy at the prescribed dose, your vet can adjust down.
Can trazodone be given every day?
Trazodone can be used short-term daily (e.g. during a 2-week post-surgical recovery) or only as-needed (e.g. before storms). Long-term daily use should be supervised by a vet.
Can RexVet prescribe trazodone for my dog?
Yes, if your dog has a current vet relationship. RexVet veterinarians can prescribe trazodone for situational anxiety, refills, or post-procedure recovery via video visit.
What if my dog is still anxious after trazodone?
Don't give a second dose without veterinary guidance. Some dogs need a higher dose, others need a different drug or a combination. A RexVet video visit can adjust the plan.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.