Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM
Cytopoint for Dogs
Cytopoint is a prescription injection that controls itch from atopic dermatitis in dogs. One injection lasts 4-8 weeks, making it a popular alternative to daily Apoquel.
What Cytopoint is used for in dogs
- Itching from atopic dermatitis
- Allergic skin disease
- Chronic itch unresponsive to other treatments
How it works
Cytopoint is a monoclonal antibody that neutralizes IL-31, the cytokine that triggers the itch signal in dogs. It works only on dog IL-31, so it has a very targeted, gentle profile.
Available formulations
Injectable solution (vet-administered)
Side effects to know
Common side effects
- • Rare — most dogs have no observable side effects
These usually resolve on their own. If they persist past the first few doses, ask your vet.
Call your vet immediately if you see
- ⚠ Allergic reaction at injection site (uncommon)
- ⚠ Lethargy
- ⚠ Vomiting (rare)
Drug interactions
- • No known significant interactions
When not to use
- • Dogs with documented hypersensitivity to Cytopoint
Monitoring during treatment
Effectiveness varies by dog. If itch returns sooner than 4 weeks, talk to your vet about combining with other approaches.
Need a Cytopoint refill?
RexVet is the first 501(c)(3) non-profit online vet service in the U.S. Talk to a licensed veterinarian by video, get your dogs's Cytopoint prescription, and have it shipped through RexVetRx — all for $64.99 per visit.
Book a vet visit — $64.99Cytopoint for Dogs
Frequently asked questions
How long does Cytopoint last?
Most dogs get 4-8 weeks of itch relief per injection. Some get less; rare dogs respond longer.
Cytopoint vs Apoquel?
Cytopoint is a monthly injection at the vet; Apoquel is a daily oral pill at home. Cytopoint is targeted at the IL-31 itch pathway; Apoquel blocks JAK enzymes more broadly. Many dogs do well on either; some respond better to one.
Is Cytopoint safe long-term?
Yes — Cytopoint has a strong safety profile and is approved for long-term use. Because it's targeted, it doesn't broadly suppress the immune system.
Can RexVet prescribe Cytopoint?
Cytopoint must be administered by a vet (it's injectable). RexVet can advise whether Cytopoint is a fit for your dog and refer you to an in-person clinic for the injection.
Can I combine Cytopoint with Apoquel?
Some vets do combine them for severe cases, especially during transitions. Always under vet supervision.
Medical review by Dr. Tiffany Delacruz, DVM
Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.
Last fact-checked: 2026-05-19
Sources
This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.