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Medication Guide • Reviewed by Dr. Tiffany Delacruz, DVM

Clavamox for Dogs

Clavamox is amoxicillin combined with clavulanic acid, which prevents bacteria from breaking down the antibiotic. Used for resistant skin, urinary, and other bacterial infections.

Generic: amoxicillin + clavulanic acid Class: Penicillin-class antibiotic with beta-lactamase inhibitor Prescription required FDA-approved for dogs
Important: This page is an educational reference. Never start, stop, or change your pet's medication without veterinary guidance. Specific dosing depends on your pet's weight, condition, and other medications. To discuss a personalized prescription or a refill request where state rules allow, talk to a licensed RexVet veterinarian.

What Clavamox is used for in dogs

  • Resistant skin infections
  • Urinary tract infections
  • Soft tissue infections
  • Dental infections
  • Some respiratory infections

How it works

Amoxicillin disrupts bacterial cell walls; clavulanic acid blocks the bacterial enzymes (beta-lactamases) that resistant bacteria use to destroy amoxicillin.

Available formulations

62.5 mg tablet

125 mg tablet

250 mg tablet

375 mg tablet

Oral drops

Side effects to know

Common side effects

  • • Mild GI upset
  • • Diarrhea
  • • Decreased appetite

These usually resolve on their own. If they persist past the first few doses, ask your vet.

Call your vet immediately if you see

  • ⚠ Severe allergic reaction
  • ⚠ Severe persistent diarrhea
  • ⚠ Yeast overgrowth

Drug interactions

  • • Probenecid increases levels
  • • Other antibiotics in same class

When not to use

  • • Penicillin allergy
  • • Severe kidney disease (dose adjustment)

Monitoring during treatment

Complete the full course to prevent resistance. Give with food to reduce GI side effects.

Need a Clavamox refill?

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Clavamox for Dogs

Frequently asked questions

Clavamox vs amoxicillin — which is stronger?

Clavamox covers more bacteria, especially resistant strains that have learned to break down plain amoxicillin. Your vet picks based on the type and history of infection.

How long does my dog need to take Clavamox?

Usually 7-14 days for routine infections; 4-6 weeks for skin infections. Always finish the full course.

Can RexVet prescribe Clavamox?

If the veterinarian decides medication is appropriate, they can prescribe where state rules allow; some medications need an in-person exam first.

Why is Clavamox more expensive than amoxicillin?

The added clavulanic acid is patented (under various brand names), so it costs more than generic amoxicillin. Many vets use plain amoxicillin first and reserve Clavamox for resistant cases.

Can I give Clavamox with food?

Yes — giving with food helps reduce stomach upset.

What is Clavamox used for in dogs?

On the FDA label, Clavamox is approved for dogs with skin and soft tissue infections, including wounds, abscesses, cellulitis and pyoderma, and for periodontal (dental) infections. Vets also prescribe it for urinary tract infections and some respiratory infections when the bacteria involved are likely to respond. The label cautions that giving an antibiotic without a proven or strongly suspected bacterial infection is unlikely to help and can promote resistance, so a vet confirms the infection first.

Can puppies take Clavamox?

Yes, when a veterinarian prescribes it. The label's dog indications include juvenile pyoderma, a puppy skin infection, and it sets no minimum age; Clavamox also comes as oral drops, which vets often use for small patients. The vet calculates the amount from the puppy's weight and picks the length of the course, so never give a puppy tablets meant for an adult dog. Puppies are more easily dehydrated, so call your vet if diarrhea or vomiting appears during treatment.

Is Clavamox an antibiotic?

Yes. Clavamox combines amoxicillin, a penicillin-class antibiotic, with clavulanate potassium, a beta-lactamase inhibitor that stops resistant bacteria from breaking amoxicillin down. That combination is why a vet may reach for it when plain amoxicillin is not expected to work. Because it contains a penicillin, the label says it should not be given to dogs with a history of allergic reaction to penicillins or cephalosporins, and the most commonly reported side effects are loss of appetite, lethargy, vomiting and diarrhea.

Medical review by Dr. Tiffany Delacruz, DVM

Chief Executive Officer & Lead Veterinarian, RexVet. Licensed in Florida, New York, and Virginia.

Last fact-checked: 2026-05-19

Sources

This page is an educational reference and does not replace veterinary advice. Always consult a licensed veterinarian before starting, changing, or stopping medication for your pet.