Dr. Tiffany Delacruz, DVM • Chief Executive Officer, RexVet • 2026-07-04 • 6 min read
Get Simparica Trio Prescription Online — $64.99 FL, NY & VA Licensed Vets | RexVet
Simparica Trio for dogs in Florida, New York and Virginia. Licensed DVMs prescribe the monthly flea, tick and heartworm chewable when suitable.
Medically reviewed by Dr. Tiffany Delacruz, DVM
Book your $64.99 online vet visit now
One monthly chewable protects against fleas, ticks, heartworm, and intestinal worms — the most comprehensive oral parasite prevention on the market.
What Simparica Trio protects against
- Fleas — kills adult fleas within 8 hours, breaks the flea life cycle
- Ticks — kills 100% of ticks within 24 hours (deer ticks, American dog ticks, brown dog ticks, Lone Star ticks, Gulf Coast ticks)
- Heartworm disease — prevents heartworm infection
- Roundworms — treats and controls adult roundworms
- Hookworms — treats and controls adult hookworms
Why one monthly chewable beats stacked products
Before Simparica Trio, most owners stacked 2-3 separate products (a flea/tick product like NexGard, a heartworm product like Heartgard, and a dewormer). Simparica Trio consolidates into one monthly flavored chewable. Same-price or cheaper than the 3-product stack in most cases. Higher owner compliance because one dose = full protection.
What to have ready for your video visit
- Your dog's weight
- Date of last heartworm test (if more than 12 months, we may recommend re-testing)
- Current parasite prevention product and last dose
- Any known adverse reactions to isoxazoline class drugs (Simparica, Bravecto, NexGard, Credelio)
- Your dog's age and reproductive status
Dosing by dog weight
- 2.8-5.5 lbs: Simparica Trio for very small dogs (yellow box)
- 5.6-11 lbs: for small dogs (purple box)
- 11.1-22 lbs: for small-medium dogs (blue box)
- 22.1-44 lbs: for medium dogs (green box)
- 44.1-88 lbs: for large dogs (orange box)
- 88.1-132 lbs: for very large dogs (red box)
- One chewable per month, given with or without food
Side effects and safety
- Most dogs tolerate Simparica Trio very well
- Uncommon: mild vomiting, decreased appetite, lethargy, diarrhea after first dose
- Rare: neurologic reactions in dogs with underlying seizure disorders — isoxazoline class carries an FDA warning
- Not for cats — do not give to cats even in emergency
- Safe for pregnant, breeding, and lactating dogs (FDA-approved)
Cost transparency
$64.99 for the RexVet video visit. 6-pack of Simparica Trio typically costs $130-$180 depending on dog weight — filled by your pharmacy (Chewy, Costco, or local vet). Compare to stacked products: NexGard 6-pack ($90-$140) + Heartgard 6-pack ($40-$70) + dewormer ($20-$40) = often more expensive than Simparica Trio.
About Dr. Tiffany Delacruz — Chief Executive Officer
Our video visits are led by Dr. Tiffany Delacruz, DVM, and our licensed DVM team. Dr. Tiffany is licensed to practice veterinary medicine in Florida, New York and Virginia. She prescribes Simparica Trio for thousands of dogs each year for comprehensive year-round parasite prevention.
Emergency signals
When to contact a veterinarian
- Adverse reaction to Simparica Trio (vomiting, lethargy, tremors, seizure) — same-day vet visit
- Dog with known seizure disorder considering isoxazoline class prevention
- Missed multiple doses of heartworm prevention — re-testing may be needed before restarting
- Puppy under 8 weeks or under 2.8 lbs — not eligible for Simparica Trio yet
Frequently asked questions
Can an online vet prescribe Simparica Trio?
If the veterinarian decides it is appropriate after a video visit, they can prescribe it where state rules allow.
Do I need a heartworm test before starting Simparica Trio?
A negative heartworm test is required before starting or restarting heartworm prevention. If your dog has been on continuous heartworm prevention with a recent (within 12 months) negative test, we can typically prescribe directly where state rules allow. If more than 12 months, we may recommend re-testing at a local vet or clinic.
How much does Simparica Trio cost?
The RexVet video visit is $64.99. A 6-pack of Simparica Trio typically costs $130-$180 filled at Chewy, Costco Pet Pharmacy, or local vet retail. Total 6-month cost with one video visit typically $195-$245.
Is Simparica Trio safe for my dog?
Simparica Trio is FDA-approved and safe for the vast majority of dogs 8 weeks and older weighing at least 2.8 lbs. It is safe for pregnant, breeding, and lactating dogs. Isoxazoline class drugs (Simparica, Bravecto, NexGard, Credelio) carry an FDA warning for rare neurologic reactions, especially in dogs with underlying seizure disorders — discuss with your vet if this applies.
Can I skip a month if my dog is indoors?
Not recommended. In Florida, tick and heartworm exposure is year-round. In New York and Virginia, even winter days above freezing keep ticks active. Missed doses create a heartworm exposure window that requires re-testing before restarting. Year-round monthly Simparica Trio is standard of care in all 3 states.
What if my dog has a seizure disorder?
The isoxazoline class (Simparica, Bravecto, NexGard, Credelio) carries an FDA warning for rare neurologic reactions in dogs with underlying seizure disorders. Alternative parasite prevention exists (Heartgard Plus for heartworm + Frontline Plus topical for flea/tick, etc.). Discuss with your RexVet vet if your dog has a seizure history.
Which states can RexVet prescribe Simparica Trio in?
Florida, New York, and Virginia — where our vets are licensed. Outside these three states, our vets cannot legally prescribe.
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About the author
Dr. Tiffany Delacruz, DVM
Chief Executive Officer, RexVet
Licensed veterinarian and CEO of RexVet (Rex Vets Inc.). Practicing across Florida, New York, and Virginia via licensed telehealth. Reviews every clinical article on RexVet before publication.