Trazodone for Dogs: Dosage, Side Effects & Anxiety Relief
By RexVet
What Is Trazodone for Dogs? Medication class How it works When it’s used Veterinary visits Travel Fireworks or storms Post-surgery confinement or restricted activity It is a prescription-only medication and should always be used under veterinary guidance. Common Owner Mistakes That Delay Proper Care Giving trazodone during the stressful event instead of beforehand (it needs time to work) Stopping the medication because the dog seems “too sleepy” (mild sedation is expected) Increasing the dose without veterinary approval Expecting over-the-counter calming chews to deliver trazodone-level results (they are far less potent) Dosage and Timing: The Key to Success Trazodone should be given 90 to 120 minutes before the anticipated stressor. If adrenaline has already surged—such as during a thunderstorm or vet visit—the medication may be far less effective. Possible Side Effects Sedation Gastrointestinal upset Paradoxical excitement (rare) Safety Consideration: Serotonin Syndrome Risk factors Warning signs Key rule Red Flags and Timing Rules Go to a physical emergency clinic immediately if: The dog ingests the entire bottle (suspected overdose) A seizure occurs The dog collapses and cannot be awakened Consult a veterinarian if: The standard dose does not adequately control anxiety Dosage adjustments are needed for ongoing or repeated use
Trazodone is a commonly used veterinary medication that helps dogs cope with stressful situations safely and effectively.
Trazodone is a Serotonin Antagonist and Reuptake Inhibitor (SARI).
It increases serotonin activity in the brain, promoting a sense of well-being and calm, along with mild sedation. This helps interrupt the stress response before anxiety escalates into panic.
Trazodone is considered a gold-standard option for situational anxiety, including:
Some frequent errors can reduce effectiveness or create unnecessary risks:
Timing matters as much as dosage.
Dogs may appear sleepy or slightly unsteady (ataxia). This is common and usually temporary.
Some dogs may experience vomiting or diarrhea, especially on an empty stomach. Giving the medication with food can help.
In uncommon cases, dogs may become more restless or hyperactive instead of calmer.
Trazodone is generally safe, but drug interactions matter.
Combining trazodone with other medications that affect serotonin—such as SSRIs (for example, fluoxetine/Prozac) or MAOIs—can increase the risk of serotonin syndrome.
High fever, tremors, muscle rigidity, agitation, or seizures.
Never combine behavioral medications without direct veterinary supervision.
Do you need trazodone for an upcoming trip, storm season, or vet visit? RexVet veterinarians can review your dog’s history and prescribe trazodone online to help keep your dog calm and safe. Book your appointment today.